Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations

Abstract

We analyzed genome-wide association data from 1,380 Europeans with early-onset and morbid adult obesity and 1,416 age-matched normal-weight controls. Thirty-eight markers showing strong association were further evaluated in 14,186 European subjects. In addition to FTO and MC4R, we detected significant association of obesity with three new risk loci in NPC1 (endosomal/lysosomal Niemann-Pick C1 gene, P = 2.9 × 10−7), near MAF (encoding the transcription factor c-MAF, P = 3.8 × 10−13) and near PTER (phosphotriesterase-related gene, P = 2.1 × 10−7).

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Farooqi, I.S. & O'Rahilly, S. Obes. Rev. 8 Suppl 1, 37–40 (2007).

    Article  PubMed  Google Scholar 

  2. 2

    Sladek, R. et al. Nature 445, 881–885 (2007).

    CAS  Article  Google Scholar 

  3. 3

    Loos, R.J. et al. Nat. Genet. 40, 768–775 (2008).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  4. 4

    Benjamini, Y. & Hochberg, Y. J. R. Stat. Soc. Ser. B Stat. Methodol. 57, 289–300 (1995).

    Google Scholar 

  5. 5

    Marchini, J., Howie, B., Myers, S., McVean, G. & Donnelly, P. Nat. Genet. 39, 906–913 (2007).

    CAS  Article  Google Scholar 

  6. 6

    Chang, T.Y. et al. J. Biol. Chem. 280, 20917–20920 (2005).

    CAS  Article  PubMed  Google Scholar 

  7. 7

    Amigo, L. et al. Hepatology 36, 819–828 (2002).

    CAS  Article  PubMed  Google Scholar 

  8. 8

    Ikonen, E. Nat. Rev. Mol. Cell Biol. 9, 125–138 (2008).

    CAS  Article  PubMed  Google Scholar 

  9. 9

    Vance, J.E. FEBS Lett. 580, 5518–5524 (2006).

    CAS  Article  PubMed  Google Scholar 

  10. 10

    Xie, C., Turley, S.D., Pentchev, P.G. & Dietschy, J.M. Am. J. Physiol. 276, E336–E344 (1999).

    CAS  PubMed  Google Scholar 

  11. 11

    Agnello, D. et al. J. Clin. Immunol. 23, 147–161 (2003).

    CAS  Article  PubMed  Google Scholar 

  12. 12

    Tsuchiya, M. et al. Pancreas 32, 408–416 (2006).

    Article  PubMed  Google Scholar 

  13. 13

    Serria, M.S. et al. Biochem. Biophys. Res. Commun. 310, 318–326 (2003).

    CAS  Article  PubMed  Google Scholar 

  14. 14

    Qi, L., Zhang, C., van Dam, R.M. & Hu, F.B. J. Clin. Endocrinol. Metab. 92, 3618–3625 (2007).

    CAS  Article  PubMed  Google Scholar 

  15. 15

    Liu, B. et al. Biochem. Biophys. Res. Commun. 293, 1396–1404 (2002).

    CAS  Article  PubMed  Google Scholar 

Download references

Acknowledgements

We thank the subjects and families who participated in this study. This work was supported by grants from the “Agence Nationale de la Recherche,” the “Conseil Regional Nord-Pas de Calais/Fonds européen de développement économique et régional,” Genome Quebec/Genome Canada and the Medical Research Council. The German cohorts and projects were supported by grants from the German Research Council (KFO152 “Atherobesity”). We thank F. Allegaert, M. Deweirder, R. Tauscher and A. Berthold for their technical support in DNA extraction and distribution. We thank P. Bougnères and C. Le Stunff for providing DNA samples of the “Saint Vincent de Paul” obese children cohort. Northern Finland Birth Cohort 1986 (NFBC1986) was supported by the European Commission; contract number QLG1-CT-2000-01643, Biocenter, University of Oulu, Finland and the Academy of Finland. We thank L. Peltonen for providing NFBC1986 DNA samples. We acknowledge the “Centre de Médecine Préventive (CMP) de Vandoeuvre les Nancy” where the STANISLAS cohort was recruited.

Author information

Affiliations

Authors

Contributions

Writing team: D.M., P.F., J.-C.C., A.I.F.B., M.I.M., A.W., C.D., R.S.; all others reviewed and approved the manuscript. Project management: D.M., J.D., A.W., C.D., P.F. Genome-wide association sampling and genotyping: D.M., J.D., S.L., E.D., J.T., M.M., M.T., S.V.-S., R.S., B.H., A.M., C.P., B.B. Confirmation study sampling and genotyping: D.M., J.D., E.D., V.V., A.K., P.K., W.K., J.T., M.M., A.L.H., P.E., F.H., N.P., S.H., C.L-.M., F.P., B.H., J.W., M.-R.J., B.B. Statistical analysis and informatics: D.M., C.L., S.G., F.D., C.P., S.G., L.J.M.C., J.A., D.B., C.D. Candidate gene analysis: J.C.C., D.M., S.G., F.D., S.G.

Corresponding author

Correspondence to Philippe Froguel.

Supplementary information

Supplementary Text and Figures

Supplementary Figures 1 and 2, Supplementary Tables 1–4 and Supplementary Methods (PDF 1279 kb)

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Meyre, D., Delplanque, J., Chèvre, JC. et al. Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nat Genet 41, 157–159 (2009). https://doi.org/10.1038/ng.301

Download citation

Further reading

Search

Quick links