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  • A Corrigendum to this article was published on 01 April 2009

This article has been updated

Abstract

We identified a marker in LINGO1 showing genome-wide significant association (P = 1.2 × 10−9, odds ratio = 1.55) with essential tremor. LINGO1 has potent, negative regulatory influences on neuronal survival and is also important in regulating both central-nervous-system axon regeneration and oligodendrocyte maturation. Increased axon integrity observed in Lingo1 mouse knockout models highlights the potential role of LINGO1 in the pathophysiology of essential tremor.

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Change history

  • 24 March 2009

    NOTE: In the version of this article initially published, one sentence in the abstract and two sentences in the final paragraph of the paper were in error and have been modified.  The final sentence in the abstract should read:  Increased axon integrity observed in Lingo1 mouse knockout models highlights the potential role of LINGO1 in the pathophysiology of ET.  The final three sentences of the paper should read:  Axonal swellings of Purkinje cell are considered to be one of the pathological findings in essential tremor6. Increased axon integrity observed in LINGO1 mouse knockout models16 highlights the potential role of LINGO1 in the pathophysiology of ET and opens up a new field in the research into essential tremor. It is our hope that LINGO1 will point the way to new treatments for severe cases of the disease.  Finally, one reference has been added:  16. Mi, S. et al. Nat. Med. 13, 1228–1233 (2007).  These errors have been corrected in the HTML and PDF versions of the article.

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Acknowledgements

We thank the individuals taking part in this study whose contribution made this work possible. We also thank the Nurses at Krókháls (deCODE's recruitment center) and the personnel at the deCODE core facilities. The US sample was recruited through support from Emory General Clinical Research Center NIH/NCRR M01 RR00039 (CRIN Infra-structure support).

Author information

Author notes

    • Hreinn Stefansson
    • , Stacy Steinberg
    •  & Hjorvar Petursson

    These authors contributed equally to this work.

Affiliations

  1. deCODE genetics, Sturlugata 8, IS-101 Reykjavík, Iceland.

    • Hreinn Stefansson
    • , Stacy Steinberg
    • , Hjorvar Petursson
    • , Omar Gustafsson
    • , Iris H Gudjonsdottir
    • , Gudrun A Jonsdottir
    • , Stefan T Palsson
    • , Thorlakur Jonsson
    • , Jona Saemundsdottir
    • , Gyda Bjornsdottir
    • , Yvonne Böttcher
    • , Theodora Thorlacius
    • , Kristleifur Kristleifsson
    • , Unnur Thorsteinsdottir
    • , Jeffrey Gulcher
    • , Augustine Kong
    •  & Kari Stefansson
  2. Department of Neurology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.

    • Dietrich Haubenberger
    • , Alexander Zimprich
    • , Eduard Auff
    •  & Christoph Hotzy
  3. Emory Department of Neurology and Center for Neurodegenerative Diseases, Whitehead Biomedical Research Building, 505F, 615 Michael Street, Atlanta, Georgia 30322, USA.

    • Claudia M Testa
  4. Emory Department of Neurology, Wesley Woods Health Center, 1841 Clifton Road, 3rd Floor, Atlanta, Georgia 30329, USA.

    • Lisa A Miyatake
    • , Ami R Rosen
    •  & David Rye
  5. Dystonia Genetics Unit, Hertie-Institute for Clinical Brain Research, Center of Neurology, University of Tuebingen, Tuebingen, Germany.

    • Friedrich Asmus
  6. Hertie-Institute for Clinical Brain Research, Center of Neurology, University of Tuebingen, Tuebingen, Germany.

    • Ludger Schöls
  7. Department of Neurology, Klinikum Grosshadern, University of Munich, Munich, Germany.

    • Martin Dichgans
  8. Department of Neurology, Landspitalinn University Hospital, Fossvogur, IS-108 Reykjavik, Iceland.

    • Finnbogi Jakobsson
  9. Department of Neurology, Landspitalinn University Hospital, Landakot, IS-101 Reykjavik, Iceland.

    • John Benedikz
  10. University of Iceland, School of Medicine, Sturlugata 8, IS-101 Reykjavik, Iceland.

    • Unnur Thorsteinsdottir
    •  & Kari Stefansson

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Contributions

The study was designed and results were interpreted by H.S., K.S., A.K., S.S., T.J., H.P., D.H. and J.G. Subject ascertainment and recruitment was carried out by K.S., J.B., J.G., F.J., K.K., M.D., L.S., F.A., A.R.R., L.A.M., C.M.T., C.H., E.A., A.Z., D.R., G.B., D.H. and G.A.J. Genotyping and laboratory experiments were performed by T.T., J.S., S.T.P., G.A.J., O.G., U.T., Y.B. and I.H.G. Authors H.S., K.S., S.S., O.G. and Y.B. drafted the manuscript. All authors contributed to the final version of the paper.

Competing interests

Some of the authors, including Kari Stefansson (CEO of deCODE genetics), Jeffrey Gulcher (Chief Scientific Officer) and Augustine Kong (VP Statistics), are shareholders in deCODE genetics.

Corresponding author

Correspondence to Kari Stefansson.

Supplementary information

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    Supplementary Text and Figures

    Supplementary Methods, Supplementary Tables 1–4 and Supplementary Figures 1–3

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DOI

https://doi.org/10.1038/ng.299

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