Proper control of cyclin-dependent kinases ensures coordinated cell cycle progression and guards against tumorigenesis. A new study identifies the PARK2 E3 ubiquitin ligase as an important coordinator of G1/S-phase cyclin turnover and explains how mutations targeting this key cell cycle regulatory node contribute to a range of cancers.
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Bartek, J., Hodny, Z. PARK2 orchestrates cyclins to avoid cancer. Nat Genet 46, 527–528 (2014). https://doi.org/10.1038/ng.2992
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DOI: https://doi.org/10.1038/ng.2992
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