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PARK2 orchestrates cyclins to avoid cancer

Nature Genetics volume 46, pages 527528 (2014) | Download Citation

Proper control of cyclin-dependent kinases ensures coordinated cell cycle progression and guards against tumorigenesis. A new study identifies the PARK2 E3 ubiquitin ligase as an important coordinator of G1/S-phase cyclin turnover and explains how mutations targeting this key cell cycle regulatory node contribute to a range of cancers.

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Author information

Affiliations

  1. Jiri Bartek and Zdenek Hodny are at the Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.

    • Jiri Bartek
    •  & Zdenek Hodny
  2. Jiri Bartek is also at the Danish Cancer Society Research Center, Copenhagen, Denmark.

    • Jiri Bartek

Authors

  1. Search for Jiri Bartek in:

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Competing interests

The authors declare no competing financial interests.

Corresponding authors

Correspondence to Jiri Bartek or Zdenek Hodny.

About this article

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DOI

https://doi.org/10.1038/ng.2992

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