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miR-212 and miR-132 are dispensable for mouse mammary gland development

Nature Genetics volume 46, pages 802–804 (2014)Cite this article

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A previous study using mice deficient at the Mir212 and Mir132 loci reported that the encoded microRNAs (miRNAs) are important regulators of mouse mammary gland development, especially for control of the outgrowth of epithelial ducts1. These findings suggested novel miRNA-mediated regulation of mammary gland organogenesis.

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Figure 1: Mammary gland development in Mir212-Mir132−/− mice.

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Gene Expression Omnibus

References

  1. Ucar, A. et al. Nat. Genet. 42, 1101–1108 (2010).

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  2. Wales, M.M. et al. Nat. Med. 1, 570–577 (1995).

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Acknowledgements

We thank P. Nielsen for fruitful discussion and K. Chowdhury (Max Planck Institute of Biophysical Chemistry) for providing us with the Mir212-Mir132ILN/ILN line. This work was supported by funds from Max Planck Gesellschaft and DFG SFB 620 (to T.F.).

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Author notes

  1. Hiroyuki Kayo, Kotaro Kiga and Yoko Fukuda-Yuzawa: These authors contributed equally to this work.

Authors and Affiliations

  1. Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany

    Hiroyuki Kayo, Kotaro Kiga, Yoko Fukuda-Yuzawa, Sebastian Hedlund, Kazuyoshi Murakami, Inti A De La Rosa-Velazquez & Taro Fukao

  2. Department of Pathology, Yamaguchi University, Graduate School of Medicine, Yamaguchi, Japan

    Tokuhiro Kimura

  3. Center for Animal Experiments, Keio University School of Medicine, Tokyo, Japan

    Kouji Shimoda

  4. Department of Infectious Diseases, Keio University School of Medicine, Tokyo, Japan

    Masanobu Tanabe

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  1. Hiroyuki Kayo
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  2. Kotaro Kiga
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  3. Yoko Fukuda-Yuzawa
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  10. Taro Fukao
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Correspondence to Taro Fukao.

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The authors declare no competing financial interests.

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Supplementary Note, Supplementary Figures 1–13 and Supplementary Table 1. (PDF 6888 kb)

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Kayo, H., Kiga, K., Fukuda-Yuzawa, Y. et al. miR-212 and miR-132 are dispensable for mouse mammary gland development. Nat Genet 46, 802–804 (2014). https://doi.org/10.1038/ng.2990

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