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ACVR1 mutations and the genomic landscape of pediatric diffuse glioma

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Pediatric diffuse gliomas are rare but aggressive brain tumors for which effective therapies are unavailable. New studies identify recurrent mutations of the ACVR1 gene in these tumors, identify molecular subtypes and highlight differences between gliomas affecting children and adults.

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Figure 1: ACVR1 mutations in pediatric glioma.

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Correspondence to Gelareh Zadeh or Kenneth Aldape.

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Zadeh, G., Aldape, K. ACVR1 mutations and the genomic landscape of pediatric diffuse glioma. Nat Genet 46, 421–422 (2014). https://doi.org/10.1038/ng.2970

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