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RHOA mutations in peripheral T cell lymphoma

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Peripheral T cell lymphomas are rare but aggressive non-Hodgkin lymphomas derived from mature T lymphocytes or natural killer (NK) cells. New studies identify recurrent dominant-negative mutation of the RHOA GTPase gene in these lymphomas.

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Figure 1: Consequences of the p.Gly17Val alteration on RHOA function.

Katie Vicari

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Correspondence to Jan Cools.

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Cools, J. RHOA mutations in peripheral T cell lymphoma. Nat Genet 46, 320–321 (2014). https://doi.org/10.1038/ng.2937

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