Peripheral T cell lymphomas are rare but aggressive non-Hodgkin lymphomas derived from mature T lymphocytes or natural killer (NK) cells. New studies identify recurrent dominant-negative mutation of the RHOA GTPase gene in these lymphomas.
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References
Piccaluga, P.P., Tabanelli, V. & Pileri, S.A. Int. J. Hematol. 99, 219–226 (2014).
Sakata-Yanagimoto, M. et al. Nat. Genet. 46, 171–175 (2014).
Palomero, T. et al. Nat. Genet. 46, 166–170 (2014).
Yoo, H.Y. et al. Nat. Genet. 46, 371–375 (2014).
Tybulewicz, V.L.J. & Henderson, R.B. Nat. Rev. Immunol. 9, 630–644 (2009).
Zhang, S. et al. J. Biol. Chem. 270, 23934–23936 (1995).
Cleverley, S.C. et al. Oncogene 19, 13–20 (2000).
Odejide, O. et al. Blood 123, 1293–1296 (2014).
Shih, A.H. et al. Nat. Rev. Cancer 12, 599–612 (2012).
Quivoron, C. et al. Cancer Cell 20, 25–38 (2011).
Busque, L. et al. Nat. Genet. 44, 1179–1181 (2012).
Hallberg, B. & Palmer, R.H. Nat. Rev. Cancer 13, 685–700 (2013).
Koo, G.C. et al. Cancer Discov. 2, 591–597 (2012).
Bisig, B. et al. Haematologica 98, 1250–1258 (2013).
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Cools, J. RHOA mutations in peripheral T cell lymphoma. Nat Genet 46, 320–321 (2014). https://doi.org/10.1038/ng.2937
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DOI: https://doi.org/10.1038/ng.2937
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