Supplementary Figure 4: Pathway-level recurrence of somatic alterations involved in RTK-PI3K-MAPK signaling. | Nature Genetics

Supplementary Figure 4: Pathway-level recurrence of somatic alterations involved in RTK-PI3K-MAPK signaling.

From: Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma

Supplementary Figure 4

Cartoon representing the frequency of distinct non-overlapping hits in intracellular components of the PI3K-MAPK signaling pathway, as well as amplifications of receptor tyrosine kinases, in DIPG. Bars are colored according to the frequency of alterations in the present cohort: red, gain of function; blue, loss of function. IGF2R binds IGF2 ligand preventing signaling through IGF1R-PI3K and is found to have somatic missense K162R and D1830E mutations. It total, 12/26 (46%) cases harboued alteration at some point in the pathway that would be predicted to be activating.

Back to article page