Supplementary Figure 2: Pathway-level recurrence of somatic alterations involved in DNA damage response. | Nature Genetics

Supplementary Figure 2: Pathway-level recurrence of somatic alterations involved in DNA damage response.

From: Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma

Supplementary Figure 2

Cartoon representing the frequency of distinct non-overlapping hits in intracellular components of ATM/p53-mediated DNA damage and stress response signaling. Bars are colored according to the frequency of alterations in the present cohort: red, gain of function; blue, loss of function. In total, 18/26 (69%) cases harbored an alteration at some point in the pathway that would be predicted to be activating.

Back to article page