Supplementary Figure 1: Somatic mutations in TP53, PPM1D and ATM in DIPG. | Nature Genetics

Supplementary Figure 1: Somatic mutations in TP53, PPM1D and ATM in DIPG.

From: Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma

Supplementary Figure 1

Cartoon showing recurrent and non-overlapping missense and frameshift mutations in TP53 (11/26, 42%), PPM1D (6/26, 23%) and ATM (1/26, 4%), overlaid with functional protein domains and exon boundaries. TAD, p53 transactivation motif; DNA binding, p53 DNA-binding domain; PP2C, protein phosphatase 2C domain; PP2Cc, serine/threonine phosphatase, family 2C, catalytic domain; TAN, telomere length maintenance and DNA damage repair domain; FAT, FRAP, ATM and TRRAP associated domain; PI3Kc, phosphoinositide 3-kinase class I catalytic domain.

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