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The epigenetic sole of sex and dosage compensation

Sex chromosomes in mammals, birds, reptiles and fish represent many independent evolutionary events, but there is spectacular convergence and stunning parallels. A new study details the early stages of ZW differentiation and sex determination in a flatfish and the establishment of dosage compensation and sex reversal by epigenetic mechanisms including DNA methylation.

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Figure 1: Regulation of sex determination in the tongue sole.


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Correspondence to Jennifer A Marshall Graves.

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Graves, J. The epigenetic sole of sex and dosage compensation. Nat Genet 46, 215–217 (2014).

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