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Stem cell fate regulation by dynein motor protein Lis1

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Cell fate regulation is a central component of maintaining tissue homeostasis, yet the mechanisms instructing cell division diversity in tissue-specific stem cells have not been well understood. A new study uncovers a central role for microtubule motor–regulating protein Lis1 in hematopoietic stem cell fate determination and in leukemogenesis.

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Figure 1: Lis1 in symmetric division of HSCs.

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Correspondence to Britta Will or Ulrich Steidl.

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The authors declare no competing financial interests.

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Will, B., Steidl, U. Stem cell fate regulation by dynein motor protein Lis1. Nat Genet 46, 217–218 (2014). https://doi.org/10.1038/ng.2902

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