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Stem cell fate regulation by dynein motor protein Lis1


Cell fate regulation is a central component of maintaining tissue homeostasis, yet the mechanisms instructing cell division diversity in tissue-specific stem cells have not been well understood. A new study uncovers a central role for microtubule motor–regulating protein Lis1 in hematopoietic stem cell fate determination and in leukemogenesis.

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Figure 1: Lis1 in symmetric division of HSCs.


  1. 1

    Zimdahl, B. et al. Nat. Genet. 46, 245–252 (2014).

    CAS  Article  Google Scholar 

  2. 2

    Wu, M. et al. Cell Stem Cell 1, 541–554 (2007).

    CAS  Article  Google Scholar 

  3. 3

    Knoblich, J.A. Nat. Rev. Mol. Cell Biol. 11, 849–860 (2010).

    CAS  Article  Google Scholar 

  4. 4

    Cancelas, J.A. et al. Nat. Med. 11, 886–891 (2005).

    CAS  Article  Google Scholar 

  5. 5

    Doetsch, F., Petreanu, L., Caille, I., Garcia-Verdugo, J.M. & Alvarez-Buylla, A. Neuron 36, 1021–1034 (2002).

    CAS  Article  Google Scholar 

  6. 6

    Gan, B. et al. Nature 468, 701–704 (2010).

    CAS  Article  Google Scholar 

  7. 7

    Nakada, D., Saunders, T.L. & Morrison, S.J. Nature 468, 653–658 (2010).

    CAS  Article  Google Scholar 

  8. 8

    Ito, K. et al. Nat. Med. 18, 1350–1358 (2012).

    CAS  Article  Google Scholar 

  9. 9

    Hope, K.J. et al. Cell Stem Cell 7, 101–113 (2010).

    CAS  Article  Google Scholar 

  10. 10

    Kharas, M.G. et al. Nat. Med. 16, 903–908 (2010).

    CAS  Article  Google Scholar 

  11. 11

    Will, B. et al. Nat. Immunol. 14, 437–445 (2013).

    CAS  Article  Google Scholar 

  12. 12

    Green, A.S. et al. Blood 116, 4262–4273 (2010).

    CAS  Article  Google Scholar 

  13. 13

    Huang, J., Roberts, A.J., Leschziner, A.E. & Reck-Peterson, S.L. Cell 150, 975–986 (2012).

    CAS  Article  Google Scholar 

  14. 14

    Ohshiro, T., Yagami, T., Zhang, C. & Matsuzaki, F. Nature 408, 593–596 (2000).

    CAS  Article  Google Scholar 

  15. 15

    Xie, Y., Juschke, C., Esk, C., Hirotsune, S. & Knoblich, J.A. Neuron 79, 254–265 (2013).

    CAS  Article  Google Scholar 

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Correspondence to Britta Will or Ulrich Steidl.

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Will, B., Steidl, U. Stem cell fate regulation by dynein motor protein Lis1. Nat Genet 46, 217–218 (2014).

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