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Stem cell fate regulation by dynein motor protein Lis1

Nature Genetics volume 46, pages 217–218 (2014)Cite this article

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Cell fate regulation is a central component of maintaining tissue homeostasis, yet the mechanisms instructing cell division diversity in tissue-specific stem cells have not been well understood. A new study uncovers a central role for microtubule motor–regulating protein Lis1 in hematopoietic stem cell fate determination and in leukemogenesis.

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Figure 1: Lis1 in symmetric division of HSCs.

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Authors and Affiliations

  1. Britta Will is in the Department of Cell Biology and the Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, New York, New York, USA.,

    Britta Will

  2. Ulrich Steidl is in the Department of Cell Biology, the Department of Medicine (Oncology) and the Albert Einstein Cancer Center, the Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine/Montefiore Medical Center, New York, New York, USA.,

    Ulrich Steidl

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  1. Britta Will
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  2. Ulrich Steidl
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Correspondence to Britta Will or Ulrich Steidl.

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The authors declare no competing financial interests.

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Will, B., Steidl, U. Stem cell fate regulation by dynein motor protein Lis1. Nat Genet 46, 217–218 (2014). https://doi.org/10.1038/ng.2902

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