Although dozens of common variants have been associated with increased risk of type 2 diabetes (T2D), the mechanisms by which these variants increase disease susceptibility are largely unknown. A new study mapping the human pancreatic islet cistrome provides a roadmap for exploring the effects of these variants and suggests that altered enhancer function might be a common contributor to the genetic risk of T2D.
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The authors declare no competing financial interests.
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Avrahami, D., Kaestner, K. A cistrome roadmap for understanding pancreatic islet biology. Nat Genet 46, 95–96 (2014). https://doi.org/10.1038/ng.2880