Genomic aberrations affecting genes in B cell differentiation are hallmarks of B-precursor acute lymphoblastic leukemia (ALL). A new whole-genome sequencing study of ETV6-RUNX1–positive ALL has now identified RAG-mediated recombination, which specifically targets genes and regulatory elements active during B cell differentiation, as the underlying mechanism.
This is a preview of subscription content, access via your institution
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Rent or buy this article
Prices vary by article type
Prices may be subject to local taxes which are calculated during checkout
Pui, C.H. et al. J. Clin. Oncol. 29, 551–565 (2011).
Mullighan, C.G. et al. Nature 446, 758–764 (2007).
Kuiper, R.P. et al. Leukemia 21, 1258–1266 (2007).
Papaemmanuil, E. et al. Nat. Genet. 46, 116–125 (2014).
Wiemels, J.L. et al. Lancet 354, 1499–1503 (1999).
Matthews, A.G. et al. Nature 450, 1106–1110 (2007).
Liu, Y. et al. Immunity 27, 561–571 (2007).
Tsuziki, S. et al. Proc. Natl. Acad. Sci. USA 101, 8443–8448 (2004).
Waanders, E. et al. PLoS Genet. 8, e1002533 (2012).
Anderson, K. et al. Nature 469, 356–361 (2011).
Iacobucci, I. et al. Blood 114, 2159–2167 (2009).
Mullighan, C.G. et al. Nature 453, 110–114 (2008).
Marculescu, R. et al. J. Exp. Med. 195, 85–98 (2002).
Raschke, S. et al. Genes Chromosom. Cancer 42, 58–67 (2005).
The authors declare no competing financial interests.
About this article
Cite this article
Kuiper, R., Waanders, E. A RAG driver on the road to pediatric ALL. Nat Genet 46, 96–98 (2014). https://doi.org/10.1038/ng.2879