Genomic aberrations affecting genes in B cell differentiation are hallmarks of B-precursor acute lymphoblastic leukemia (ALL). A new whole-genome sequencing study of ETV6-RUNX1–positive ALL has now identified RAG-mediated recombination, which specifically targets genes and regulatory elements active during B cell differentiation, as the underlying mechanism.
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Pui, C.H. et al. J. Clin. Oncol. 29, 551–565 (2011).
Mullighan, C.G. et al. Nature 446, 758–764 (2007).
Kuiper, R.P. et al. Leukemia 21, 1258–1266 (2007).
Papaemmanuil, E. et al. Nat. Genet. 46, 116–125 (2014).
Wiemels, J.L. et al. Lancet 354, 1499–1503 (1999).
Matthews, A.G. et al. Nature 450, 1106–1110 (2007).
Liu, Y. et al. Immunity 27, 561–571 (2007).
Tsuziki, S. et al. Proc. Natl. Acad. Sci. USA 101, 8443–8448 (2004).
Waanders, E. et al. PLoS Genet. 8, e1002533 (2012).
Anderson, K. et al. Nature 469, 356–361 (2011).
Iacobucci, I. et al. Blood 114, 2159–2167 (2009).
Mullighan, C.G. et al. Nature 453, 110–114 (2008).
Marculescu, R. et al. J. Exp. Med. 195, 85–98 (2002).
Raschke, S. et al. Genes Chromosom. Cancer 42, 58–67 (2005).
The authors declare no competing financial interests.
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Kuiper, R., Waanders, E. A RAG driver on the road to pediatric ALL. Nat Genet 46, 96–98 (2014). https://doi.org/10.1038/ng.2879