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A RAG driver on the road to pediatric ALL

Genomic aberrations affecting genes in B cell differentiation are hallmarks of B-precursor acute lymphoblastic leukemia (ALL). A new whole-genome sequencing study of ETV6-RUNX1–positive ALL has now identified RAG-mediated recombination, which specifically targets genes and regulatory elements active during B cell differentiation, as the underlying mechanism.

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Figure 1: Off-target RAG-mediated recombination in ETV6-RUNX1–positive ALL predominantly occurs at RSS-like motifs (gray triangles) in accessible, H3K4me3-marked (yellow pentagons) open chromatin.


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Correspondence to Roland P Kuiper.

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Kuiper, R., Waanders, E. A RAG driver on the road to pediatric ALL. Nat Genet 46, 96–98 (2014).

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