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Genetic signature of bacterial pathogen adaptation during chronic pulmonary infections

To establish and maintain chronic infections, many pathogens adapt in response to selective pressures within the host, leaving unique genetic signatures. A new study uses whole-genome and population sequencing approaches to identify evidence of adaptive evolution in Burkholderia dolosa genomes isolated from chronic infections in patients with cystic fibrosis.

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Figure 1: Population heterogeneity of pathogens within cystic fibrosis airways.


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Correspondence to Michael G Surette.

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Bernier, S., Workentine, M. & Surette, M. Genetic signature of bacterial pathogen adaptation during chronic pulmonary infections. Nat Genet 46, 5–6 (2014).

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