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Genetic signature of bacterial pathogen adaptation during chronic pulmonary infections

Nature Genetics volume 46, pages 56 (2014) | Download Citation

To establish and maintain chronic infections, many pathogens adapt in response to selective pressures within the host, leaving unique genetic signatures. A new study uses whole-genome and population sequencing approaches to identify evidence of adaptive evolution in Burkholderia dolosa genomes isolated from chronic infections in patients with cystic fibrosis.

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Author information

Affiliations

  1. Steve P. Bernier, Matthew L. Workentine and Michael G. Surette are at the Farncombe Family Digestive Health Research Institute, Faculty of Health Sciences, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

    • Steve P Bernier
    • , Matthew L Workentine
    •  & Michael G Surette

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Michael G Surette.

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DOI

https://doi.org/10.1038/ng.2859

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