Epigenetics, vitamin supplements and cellular reprogramming

The simple addition of vitamin C to cell culture medium can induce extensive remodeling of the cellular epigenome and facilitates reprogramming of somatic cells to pluripotency. A new study shows that the activity of the enzyme TET1 can inhibit or enhance reprogramming efficiency, dependent on the presence or absence of vitamin C.

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Figure 1: The effects of TET1 deficiency are dependent on the presence of vitamin C in the medium.

Katie Vicari

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Correspondence to Martin F Pera.

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Pera, M. Epigenetics, vitamin supplements and cellular reprogramming. Nat Genet 45, 1412–1413 (2013). https://doi.org/10.1038/ng.2834

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