Comprehensive sequencing of benign and malignant tumors has recently uncovered new driver mutations in childhood tumors. A new report now describes frequent histone H3.3 alterations in chondroblastoma and giant cell tumor of bone, emphasizing the importance of this histone variant in pediatric cancers.
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Lindroth, A., Plass, C. Recurrent H3.3 alterations in childhood tumors. Nat Genet 45, 1413–1414 (2013). https://doi.org/10.1038/ng.2832
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DOI: https://doi.org/10.1038/ng.2832
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