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The search for ESR1 mutations in breast cancer

Nature Genetics volume 45, pages 14151416 (2013) | Download Citation

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Two new studies report the identification of activating ESR1 gene mutations in aromatase inhibitor–resistant metastatic breast cancers. This insight into therapeutic resistance suggests new approaches that may be useful in the management of endocrine-resistant breast cancer.

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Author information

Affiliations

  1. Steffi Oesterreich and Nancy E. Davidson are in the Department of Pharmacology and Chemical Biology and Department of Medicine, University of Pittsburgh, Women's Cancer Research Center, University of Pittsburgh Cancer Institute and UPMC Cancer Center, and Magee-Womens Research Institute, Pittsburgh, Pennsylvania, USA.

    • Steffi Oesterreich
    •  & Nancy E Davidson

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Nancy E Davidson.

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DOI

https://doi.org/10.1038/ng.2831

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