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No pain, more gain

A new study shows that a specific mutation in SCN11A, which encodes the Nav1.9 voltage-gated sodium channel, underlies a human disorder characterized by insensitivity to pain. This finding provides fresh insights into human pain perception and suggests a new avenue for the development of analgesic drugs.

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Correspondence to John N Wood.

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Cox, J., Wood, J. No pain, more gain. Nat Genet 45, 1271–1272 (2013). https://doi.org/10.1038/ng.2810

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