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Mining the epigenetic landscape in ALL

Nature Genetics volume 45, pages 1269–1270 (2013)Cite this article

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The significance of epigenomic aberrations in cancer development has been underscored by the discovery of mutations in key chromatin modifiers, most notably in hematological malignancies. A new study of pediatric acute lymphoblastic leukemia (ALL) demonstrates the usefulness of mapping global epigenetic signatures and applying these data in a framework to identify and characterize underlying somatic genetic alterations in human cancers.

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Figure 1: Schematic of the chromatin signature that was studied by Stegmeier and colleagues.

Katie Vicari

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Authors and Affiliations

  1. Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA

    Lindsay M LaFave & Ross L Levine

  2. Gerstner Sloan-Kettering Graduate School, Memorial Sloan-Kettering Cancer Center, New York, New York, USA

    Lindsay M LaFave

  3. Department of Medicine, Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, New York, USA

    Ross L Levine

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  1. Lindsay M LaFave
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  2. Ross L Levine
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Correspondence to Ross L Levine.

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LaFave, L., Levine, R. Mining the epigenetic landscape in ALL. Nat Genet 45, 1269–1270 (2013). https://doi.org/10.1038/ng.2808

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