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Linking the SWI/SNF complex to prostate cancer

Genes encoding subunits of the SWI/SNF chromatin-remodeling complex constitute, collectively, one of the most frequently mutated targets in cancer. Although mutations in SWI/SNF genes are uncommon in prostate cancer, a new study shows that SChLAP1, a long noncoding RNA frequently expressed in aggressive prostate tumors, drives cancer by directly disrupting SNF5, a core subunit of the SWI/SNF complex.

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Figure 1: Aberrantly high expression of SChLAP1 in aggressive prostate cancers inhibits SWI/SNF-mediated epigenetic regulation.


  1. Siegel, R., Naishadham, D. & Jemal, A. CA Cancer J. Clin. 63, 11–30 (2013).

    Article  Google Scholar 

  2. Varambally, S. et al. Nature 419, 624–629 (2002).

    Article  CAS  Google Scholar 

  3. Prensner, J.R. & Chinnaiyan, A.M. Cancer Discov. 1, 391–407 (2011).

    Article  CAS  Google Scholar 

  4. Du, Z. et al. Nat. Struct. Mol. Biol. 20, 908–913 (2013).

    Article  CAS  Google Scholar 

  5. Prensner, J.R. et al. Nat. Biotechnol. 29, 742–749 (2011).

    Article  CAS  Google Scholar 

  6. Yang, L. et al. Nature 500, 598–602 (2013).

    Article  CAS  Google Scholar 

  7. Prensner, J.R. et al. Nat. Genet. 45, 1392–1398 (2013).

    Article  CAS  Google Scholar 

  8. Wilson, B.G. & Roberts, C.W.M. Nat. Rev. Cancer 11, 481–492 (2011).

    Article  CAS  Google Scholar 

  9. Lee, R.S. et al. J. Clin. Invest. 122, 2983–2988 (2012).

    Article  CAS  Google Scholar 

  10. Kadoch, C. et al. Nat. Genet. 45, 592–601 (2013).

    Article  CAS  Google Scholar 

  11. Kadoch, C. & Crabtree, G.R. Cell 153, 71–85 (2013).

    Article  CAS  Google Scholar 

  12. You, J.S. et al. PLoS Genet. 9, e1003459 (2013).

    Article  CAS  Google Scholar 

  13. Tolstorukov, M.Y. et al. Proc. Natl. Acad. Sci. USA 110, 10165–10170 (2013).

    Article  CAS  Google Scholar 

  14. Link, K.A. et al. Cancer Res. 68, 4551–4558 (2008).

    Article  CAS  Google Scholar 

  15. Balasubramaniam, S. et al. Clin. Cancer Res. 19, 2657–2667 (2013)

    Article  CAS  Google Scholar 

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Correspondence to Charles W M Roberts.

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Lee, R., Roberts, C. Linking the SWI/SNF complex to prostate cancer. Nat Genet 45, 1268–1269 (2013).

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