Three new studies have used whole-genome sequencing of M. tuberculosis to demonstrate unexpected complexity in the modern evolution of drug-resistant tuberculosis, and a fourth study suggests a close evolutionary relationship between the pathogen and its human host over a period of 70,000 years. Collectively, the observations in these studies suggest that future strategies to tackle drug-resistant tuberculosis must integrate host genetics with detailed strain epidemiology.
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Warner, D., Mizrahi, V. Complex genetics of drug resistance in Mycobacterium tuberculosis. Nat Genet 45, 1107–1108 (2013). https://doi.org/10.1038/ng.2769
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DOI: https://doi.org/10.1038/ng.2769
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