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Common 5p15.33 and 6p21.33 variants influence lung cancer risk

Nature Genetics volume 40, pages 1407–1409 (2008)Cite this article

Abstract

We conducted a genome-wide association (GWA) study of lung cancer comparing 511,919 SNP genotypes in 1,952 cases and 1,438 controls. The most significant association was attained at 15q25.1 (rs8042374; P = 7.75 × 10−12), confirming recent observations. Pooling data with two other GWA studies (5,095 cases, 5,200 controls) and with replication in an additional 2,484 cases and 3,036 controls, we identified two newly associated risk loci mapping to 6p21.33 (rs3117582, BAT3-MSH5; Pcombined = 4.97 × 10−10) and 5p15.33 (rs401681, CLPTM1L; Pcombined = 7.90 × 10−9).

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Figure 1: Summary of association results for rs3117582 and rs401681.
Figure 2: LD structure and association results for the two confirmed lung cancer–associated regions.

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Acknowledgements

Cancer Research UK (A1298/A8780) provided principal funding for this study. Additional funding was provided by HEAL and Sanofi-Aventis and US NIH Grants P50CA70907, R01CA121197 and R01CA133996. We would like to thank all individuals who participated in this study. We are grateful to colleagues at UK Clinical Genetics Centres and the UK National Cancer Research Network.

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Author notes

  1. Timothy Eisen, Christopher I Amos and Richard S Houlston: These authors contributed equally to this work.

Authors and Affiliations

  1. Section of Cancer Genetics, Institute of Cancer Research, Sutton, SM2 5NG, Surrey, UK

    Yufei Wang, Peter Broderick, Emily Webb, Jayaram Vijayakrishnan, Athena Matakidou, Mobshra Qureshi & Richard S Houlston

  2. Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, 77030, Texas, USA

    Xifeng Wu, Qiong Dong, Xiangjun Gu, Wei Vivien Chen, Margaret R Spitz & Christopher I Amos

  3. Department of Oncology, University of Cambridge, Cambridge, CB2 2RE, UK

    Timothy Eisen

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  1. Yufei Wang
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Contributions

R.S.H. designed the study, with substantial contributions from C.I.A. and T.E. R.S.H. drafted the manuscript, with substantial contributions from E.W. and C.I.A. T.E., R.S.H. and A.M. oversaw sample and data collection of cases for the UK study. P.B. oversaw the genotyping for the UK study. P.B. managed samples for the UK study. J.V. and M.Q. performed sample preparation for the UK study. Y.W. performed statistical and bioinformatics analyses for the UK study. Y.W. and E.W. performed statistical and bioinformatics analyses for the meta-analysis. M.R.S. oversaw sample and data collection of cases for the Texas study. C.I.A. oversaw the GWA genotyping and analyses for the Texas Study. X.W. managed samples for the Texas study. X.G., W.V.C. and Q.D. performed analyses and curated data for the Texas study. All authors contributed to the final paper.

Corresponding author

Correspondence to Richard S Houlston.

Supplementary information

Supplementary Text and Figures

Supplementary Figures 1–3, Supplementary Table 2 and Supplementary Methods (PDF 664 kb)

Supplementary Table 1

Meta-analysis results (XLS 96 kb)

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Wang, Y., Broderick, P., Webb, E. et al. Common 5p15.33 and 6p21.33 variants influence lung cancer risk. Nat Genet 40, 1407–1409 (2008). https://doi.org/10.1038/ng.273

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