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A developmental program for Candida commensalism

Nature Genetics volume 45, pages 967968 (2013) | Download Citation

Candida albicans is a frequent pathogen of immunologically compromised individuals, but it is an even more common commensal of healthy humans, where it resides in the gut in a benign state. A new study shows that a specific commensal form of the fungus is induced in the gut through a developmental program that downregulates virulence factors and induces metabolic functions, enabling it to thrive on the nutrients that are available in the large intestine without damaging its host.

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References

  1. 1.

    , & Nat. Genet. 45, 1088–1091 (2013).

  2. 2.

    et al. Sci.Transl. Med. 4, 165rv13 (2012).

  3. 3.

    & Cell 110, 293–302 (2002).

  4. 4.

    & Curr. Opin. Microbiol. 15, 406–412 (2012).

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Author information

Affiliations

  1. Neil A.R. Gow is in the Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.

    • Neil A R Gow

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Competing interests

The author declares no competing financial interests.

Corresponding author

Correspondence to Neil A R Gow.

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DOI

https://doi.org/10.1038/ng.2737

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