Recent studies have identified recurrent mutations in SETBP1, the gene that encodes SET-binding protein 1, in several types of myeloid malignancies, including chronic myeloid and acute myeloid leukemias. The identified mutations frequently target the SKI-homologous domain, although the exact pathogenic mechanisms remain unknown.
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Trimarchi, T., Ntziachristos, P. & Aifantis, I. A new player SETs in myeloid malignancy. Nat Genet 45, 846–847 (2013). https://doi.org/10.1038/ng.2709
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