Two recent studies describe the largest molecular profiling analyses to date of clear-cell renal cell carcinoma (ccRCC) and report remarkably similar findings. The recurrent pathway alterations identified in these studies open new avenues for therapeutic advances in this chemotherapy- and radiation-resistant disease.
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References
Zbar, B., Brauch, H., Talmadge, C. & Linehan, M. Nature 327, 721–724 (1987).
Gnarra, J.R. et al. Nat. Genet. 7, 85–90 (1994).
Herman, J.G. et al. Proc. Natl. Acad. Sci. USA 91, 9700–9704 (1994).
Varela, I. et al. Nature 469, 539–542 (2011).
Dalgliesh, G.L. et al. Nature 463, 360–363 (2010).
Guo, G. et al. Nat. Genet. 44, 17–19 (2012).
Sato, X. et al. Nat. Genet. 45, 860–867 (2013).
The Cancer Genome Atlas Research Network. Nature published online; doi:10.1038/nature12222 (23 June 2013).
Linehan, W.M., Srinivasan, R. & Schmidt, L.S. Nat. Rev. Urol. 7, 277–285 (2010).
Kapur, P. et al. Lancet Oncol. 14, 159–167 (2013).
Hakimi, A.A. et al. Eur. Urol. 63, 848–854 (2013).
Hakimi, A.A. et al. Clin. Cancer Res. 19, 3259–3267 (2013).
Shen, C. et al. Cancer Discov. 1, 222–235 (2011).
Yang, H. et al. Nature 497, 217–223 (2013).
Motzer, R.J. et al. Lancet 372, 449–456 (2008).
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Hakimi, A., Pham, C. & Hsieh, J. A clear picture of renal cell carcinoma. Nat Genet 45, 849–850 (2013). https://doi.org/10.1038/ng.2708
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DOI: https://doi.org/10.1038/ng.2708
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