Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Leveraging the species barrier to advance cancer therapy

The discovery of new therapeutic targets and the personalization of treatments are two active areas of cancer research. New studies suggest that a 'co-clinical' approach may expedite both therapeutic target validation and risk stratification in patients with advanced prostate cancer.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Figure 1: Schematic of the cross-species approach for identifying and evaluating therapeutic targets.


  1. Lunardi, A. et al. Nat. Genet. 45, 747–755 (2013).

    Article  CAS  Google Scholar 

  2. Nardella, C., Lunardi, A., Patnaik, A., Cantley, L.C. & Pandolfi, P.P. Cancer Discov. 1, 108–116 (2011).

    Article  Google Scholar 

  3. Ryan, C.J. & Tindall, D.J. J. Clin. Oncol. 29, 3651–3658 (2011).

    Article  CAS  Google Scholar 

  4. Grasso, C.S. et al. Nature 487, 239–243 (2012).

    Article  CAS  Google Scholar 

  5. Barbieri, C.E. et al. Nat. Genet. 44, 685–689 (2012).

    Article  CAS  Google Scholar 

  6. Wang, S. et al. Cancer Cell 4, 209–221 (2003).

    Article  CAS  Google Scholar 

  7. Gao, H., Ouyang, X., Banach-Petrosky, W.A., Shen, M.M. & Abate-Shen, C. Cancer Res. 66, 7929–7933 (2006).

    Article  CAS  Google Scholar 

  8. Wang, G. et al. Nat. Genet. 45, 739–746 (2013).

    Article  CAS  Google Scholar 

  9. Kumari, R. et al. Carcinogenesis 33, 2076–2083 (2012).

    Article  CAS  Google Scholar 

  10. Beroukhim, R. et al. Nature 463, 899–905 (2010).

    Article  CAS  Google Scholar 

  11. Tomlins, S.A. et al. Science 310, 644–648 (2005).

    Article  CAS  Google Scholar 

  12. Chen, C.D. et al. Nat. Med. 10, 33–39 (2004).

    Article  Google Scholar 

  13. Sun, Y. et al. Nat. Med. 18, 1359–1368 (2012).

    Article  CAS  Google Scholar 

  14. Straussman, R. et al. Nature 487, 500–504 (2012).

    Article  CAS  Google Scholar 

  15. Shah, S.K. et al. J. Urol. 181, 621–626 (2009).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Peter S Nelson.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Zhao, S., Nelson, P. Leveraging the species barrier to advance cancer therapy. Nat Genet 45, 718–720 (2013).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer