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Hypomethylation marks enhancers within transposable elements

Transposable elements (TEs) make up 50% of the human genome and are usually considered a mutational burden. A new study uses signatures of DNA hypomethylation to identify tissue-specific enhancers within TEs, providing fresh evidence that mobile DNA has a non-negligible role in genome regulation and evolution.

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Figure 1: Possible evolutionary scenarios leading to TE functionalization and DNA hypomethylation.

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Correspondence to Amos Tanay.

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Mukamel, Z., Tanay, A. Hypomethylation marks enhancers within transposable elements. Nat Genet 45, 717–718 (2013). https://doi.org/10.1038/ng.2680

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