Plasmodium falciparum in Southeast Asia are gradually becoming resistant to artemesinin, a standard first-line treatment for malaria. Whole-genome sequencing offers a chance to better understand and perhaps undermine the parasite's evolutionary response to this drug.
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References
World Health Organization. World Malaria Report 2012 (World Health Organization, Geneva, 2012).
Carlton, J.M., Escalante, A.A., Neafsey, D. & Volkman, S.K. Trends Parasitol. 24, 545–550 (2008).
Dondorp, A.M. et al. N. Engl. J. Med. 361, 455–467 (2009).
Noedl, H. et al. N. Engl. J. Med. 359, 2619–2620 (2008).
Amaratunga, C. et al. Lancet Infect. Dis. 12, 851–858 (2012).
Payne, D. Parasitol. Today 3, 241–246 (1987).
Roper, C. et al. Science 305, 1124 (2004).
Mita, T. et al. J. Infect. Dis. 204, 1980–1988 (2011).
Miotto, O. et al. Nat. Genet. 45, 648–655 (2013).
Cheeseman, I.H. et al. Science 336, 79–82 (2012).
Takala-Harrison, S. et al. Proc. Natl. Acad. Sci. U.S.A. 110, 240–245 (2013).
Hastings, I.M. Trends Parasitol. 19, 70–73 (2003).
Gregson, A. & Plowe, C.V. Pharmacol. Rev. 57, 117–145 (2005).
Price, R.N. et al. Lancet 364, 438–447 (2004).
Fivelman, Q.L., Butcher, G.A., Adagu, I.S., Warhurst, D.C. & Pasvol, G. Malar. J. 1, 1 (2002).
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Neafsey, D. Genome sequencing sheds light on emerging drug resistance in malaria parasites. Nat Genet 45, 589–590 (2013). https://doi.org/10.1038/ng.2648
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DOI: https://doi.org/10.1038/ng.2648
