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Genome sequencing sheds light on emerging drug resistance in malaria parasites

Plasmodium falciparum in Southeast Asia are gradually becoming resistant to artemesinin, a standard first-line treatment for malaria. Whole-genome sequencing offers a chance to better understand and perhaps undermine the parasite's evolutionary response to this drug.

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References

  1. World Health Organization. World Malaria Report 2012 (World Health Organization, Geneva, 2012).

  2. Carlton, J.M., Escalante, A.A., Neafsey, D. & Volkman, S.K. Trends Parasitol. 24, 545–550 (2008).

    Article  CAS  PubMed  Google Scholar 

  3. Dondorp, A.M. et al. N. Engl. J. Med. 361, 455–467 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Noedl, H. et al. N. Engl. J. Med. 359, 2619–2620 (2008).

    Article  CAS  PubMed  Google Scholar 

  5. Amaratunga, C. et al. Lancet Infect. Dis. 12, 851–858 (2012).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Payne, D. Parasitol. Today 3, 241–246 (1987).

    Article  CAS  PubMed  Google Scholar 

  7. Roper, C. et al. Science 305, 1124 (2004).

    Article  CAS  PubMed  Google Scholar 

  8. Mita, T. et al. J. Infect. Dis. 204, 1980–1988 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Miotto, O. et al. Nat. Genet. 45, 648–655 (2013).

    Article  CAS  PubMed  Google Scholar 

  10. Cheeseman, I.H. et al. Science 336, 79–82 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Takala-Harrison, S. et al. Proc. Natl. Acad. Sci. U.S.A. 110, 240–245 (2013).

    Article  CAS  PubMed  Google Scholar 

  12. Hastings, I.M. Trends Parasitol. 19, 70–73 (2003).

    Article  CAS  PubMed  Google Scholar 

  13. Gregson, A. & Plowe, C.V. Pharmacol. Rev. 57, 117–145 (2005).

    Article  CAS  PubMed  Google Scholar 

  14. Price, R.N. et al. Lancet 364, 438–447 (2004).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Fivelman, Q.L., Butcher, G.A., Adagu, I.S., Warhurst, D.C. & Pasvol, G. Malar. J. 1, 1 (2002).

    Article  PubMed  PubMed Central  Google Scholar 

Download references

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Correspondence to Daniel E Neafsey.

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Neafsey, D. Genome sequencing sheds light on emerging drug resistance in malaria parasites. Nat Genet 45, 589–590 (2013). https://doi.org/10.1038/ng.2648

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