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Putting a halt on PRC2 in pediatric glioblastoma

Two new studies show that the known histone H3 alteration p.Lys27Met in pediatric glioma leads to globally diminished trimethylation at histone H3 lysine 27. The mutant histone H3 acts as a selective inhibitor of the PRC2 chromatin-modifying complex by binding and presumably sequestering it, shedding light on how this variant may contribute to the etiology of these highly malignant brain tumors.

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Figure 1: Histone H3 Lys27Met sequesters and inhibits PRC2 on chromatin.


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Correspondence to Danny Reinberg.

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Voigt, P., Reinberg, D. Putting a halt on PRC2 in pediatric glioblastoma. Nat Genet 45, 587–589 (2013).

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