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Putting a halt on PRC2 in pediatric glioblastoma

Nature Genetics volume 45, pages 587–589 (2013)Cite this article

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Two new studies show that the known histone H3 alteration p.Lys27Met in pediatric glioma leads to globally diminished trimethylation at histone H3 lysine 27. The mutant histone H3 acts as a selective inhibitor of the PRC2 chromatin-modifying complex by binding and presumably sequestering it, shedding light on how this variant may contribute to the etiology of these highly malignant brain tumors.

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Figure 1: Histone H3 Lys27Met sequesters and inhibits PRC2 on chromatin.

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Authors and Affiliations

  1. Philipp Voigt and Danny Reinberg are at the Howard Hughes Medical Institute and the Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, New York, USA.,

    Philipp Voigt & Danny Reinberg

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  1. Philipp Voigt
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  2. Danny Reinberg
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Correspondence to Danny Reinberg.

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The authors declare no competing financial interests.

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Voigt, P., Reinberg, D. Putting a halt on PRC2 in pediatric glioblastoma. Nat Genet 45, 587–589 (2013). https://doi.org/10.1038/ng.2647

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