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Cancer chromosomes going to POT1

Alterations in the single-stranded telomere–binding protein POT1 have recently been identified in chronic lymphocytic leukemia. This discovery provides novel insights into how genomic instability induced by dysfunctional telomeres contributes to tumorigenesis.

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Figure 1: POT1 mutations in CLL promote chromosomal aberrations and telomere extension.

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Correspondence to Sandy Chang.

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Chang, S. Cancer chromosomes going to POT1. Nat Genet 45, 473–475 (2013). https://doi.org/10.1038/ng.2617

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