Abstract
Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and women of African ancestry and followed up the most significant associations in an additional 32,268 individuals of African ancestry. We identified one new locus at 5q33 (GALNT10, rs7708584, P = 3.4 × 10−11) and another at 7p15 when we included data from the GIANT consortium (MIR148A-NFE2L3, rs10261878, P = 1.2 × 10−10). We also found suggestive evidence of an association at a third locus at 6q16 in the African-ancestry sample (KLHL32, rs974417, P = 6.9 × 10−8). Thirty-two of the 36 previously established BMI variants showed directionally consistent effect estimates in our GWAS (binomial P = 9.7 × 10−7), five of which reached genome-wide significance. These findings provide strong support for shared BMI loci across populations, as well as for the utility of studying ancestrally diverse populations.
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Acknowledgements
A full listing of acknowledgments is detailed in the Supplementary Note.
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Contributions
Design and/or management of the individual studies: A.A., A.A.A., C.B.A., C.I.A., D.K.A., L.A., M.C.A., M.A.A., S.A., C.H.B., D.M.B., D.W.B., E.P.B., E.V.B., G.B., I.B.B., J.P.B., L.B., S.I.B., W.J.B., C.S.C., G. Casey, G.K.C., J.C., L.C., M.C., N.E.C., Q.C., R.S.C., S.J.C., J.D., P.D., R.W.D., S.L.D.-H., M.K.E., T.L.E., C.F., J.K.F., E.M.G., P.J.G., S.F.A.G., A.H., A.J.M.H., B.E.H., B.V.H., C.A.H., C.C.H., D.H., H.H., K.J.H., J.J.H., J.N.H., V.J.H., S.A.I., E.M.J., J.M.J., C.K., D.L.K., E.A.K., E.K.K., L.N.K., L.H.K., R.A.K., S.J.K., S. Kolb, L.L.M., A.M.L., R.J.F.L., S.L., Yongmei Liu, A.B.M., B.M., K.R.M., R.C.M., T.H.M., J.H.M., J.C.M., I.M.-B., K.E.N., M.C.Y.N., S.N., C.N.-D., U.N., B.N., K.L.N., T.O.O., O.O., O.I.O., B.P., U.P., B.M.P., C.A.P., G.J.P., J.R.P., M.F.P., P.A.P., S.R.P., E.A.R.-N., B.A.R., C.N.R., S.R., J.L.R.-G., A.B.S., A.G.S., J.L.S., L.B.S., P.J.S., S.B.S., S.W.-S., M.R.S., M.M.S., I.J.S., S.S.S., H.T., M.J.T., M.A.T., M.V., J.S.W., X.W., J.K.W., S.M.W., L.K.W., M.W., J.J.Y., N.A.Z., R.G.Z., W. Zheng, A.B.Z., K.A.Z., Y.Z. and X.Z.
Genotyping: A.B., U.B., S.J.C., Y.-D.I.C., D.D., T.L.E., S.F.A.G., X.G., D.G.H., J.N.H., T.D.H., T. Haritunians, K.C.J., Yongmei Liu, Y. Lu, W.M., R.N., J.R.P., N.D.P., S.B.S. and D.J.V.D.B.
Phenotyping: A.A.A., D.K.A., M.A.A., E.P.B., R.S.C., E.D., B.I.F., O.G., S.F.A.G., J.N.H., T. Haritunians, K.C.J., A.K., C.K., E.K.K., S.L., J.E.M., M.N., R.N., A.O., H.O.-B., B.M.P., J.R.P., S.R.P., C.N.R., E.R., S.R., B.S., D.S., L.S., B.O.T. and T.R.Y.
Statistical methods and data analysis: A.A.A., D.K.A., L.F.B., C.W.K.C., G.K.C., G. Casey, N.E.C., W.-M.C., G.A.C., Y.-D.I.C., J.D., P.D., T.L.E., C.F., M.F.F., J.P.B., E.M.G., M.G., O.G., X.G., C.A.H., M.R.I., A.K., B.J.K., C.K., E.K.K., S.J.K., C.D.L., G. Lettre, G. Li, H.L., K.L., L.A.L., R.J.F.L., V.L., Yongmei Liu, Youfang Liu, Y. Lu, B.M., K.L.M., Y.A.M., A.N., K.E.N., M.A.N., M.C.Y.N., C.P., J.R.P., E.A.R.-N., S.K.R., B.P., A.P.R., L.J.R.-T., D.A.S., E.K.S., E.E.S., Y.V.S., B.O.T., K.C.T., D.R.V.E., M.K.W., Z.W., L.K.W., T.W.W., L.R.Y., J.Z., J.H.Z., N.A.Z., J.M.Z., W. Zhao, the NABEC Consortium, the UKBEC Consortium, the BioBank Japan Project and the AGEN Consortium.
Writing group: G.K.C., T.L.E., M.G., B.E.H., J.N.H., R.J.F.L., C.A.H., L.A.L., K.L.M., K.E.N., M.C.Y.N., C.P., G.J.P., A.P.R. and K.C.T.
Critical review of the manuscript: A.A.A., A.A., C.B.A., C.I.A., D.K.A., L.A., M.A.A., M.C.A., S.A., A.B., C.H.B., D.M.B., D.W.B., E.P.B., E.V.B., G.B., I.B.B., J.P.B., L.F.B., L.B., S.I.B., U.B., W.J.B., C.W.K.C., C.S.C., F.C., G.A.C., G.K.C., G. Casey, G. Chen, J.C., L.C., M.C., N.E.C., Q.C., R.S.C., S.J.C., W.-M.C., Y.-D.I.C., D.D., E.D., J.D., P.D., R.W.D., S.L.D.-H., M.K.E., T.L.E., C.F., J.K.F., M.F.F., B.I.F., Y.F., E.M.G., G.S.G., M.G., O.G., P.J.G., S.F.A.G., W.T.G., X.G., A.J.M.H., A.H., B.E.H., B.V.H., C.A.H., C.C.H., D.G.H., D.H., H.H., J.J.H., J.N.H., K.J.H., T.D.H., T. Haritunians, T. Harris, V.J.H., J.H.M., M.R.I., S.A.I., E.M.J., J.M.J., K.C.J., A.K., B.J.K., C.K., D.L.K., E.A.K., E.K.K., L.N.K., L.H.K., R.A.K., S.J.K., S.L.R.K., S. Kolb, S. Ketkar, A.M.L., C.D.L., G. Lettre, G. Li, H.L., K.L., L.A.L., L.L., M.C.L., R.J.F.L., S.L., V.L., Yongmei Liu, Youfang Liu, Y. Lu, A.B.M., B.M., J.C.M., J.E.M., L.H.M., K.L.M., K.R.M., R.C.M., T.H.M., W.M., Y.A.M., I.M.-B., A.N., B.N., K.E.N., K.L.N., M.A.N., M.C.Y.N., M.N., R.N., S.N., U.N., C.N.-D., O.I.O., O.O., T.O.O., A.O., H.O.-B., B.M.P., B.P., C.A.P., C.P., G.J.P., J.R.P., M.F.P., N.D.P., P.A.P., S.R.P., U.P., A.P.R., B.A.R., C.N.R., E.R., S.K.R., S.R., J.L.R.-G., E.A.R.-N., L.J.R.-T., A.B.S., A.G.S., B.S., D.A.S., D.S., E.K.S., E.E.S., I.J.S., J.L.S., L.B.S., L.S., M.M.S., M.R.S., P.J.S., S.B.S., S.S.S., Y.V.S., B.O.T., K.C.T., M.A.T., H.T., M.J.T., M.V., D.J.V.D.B., D.R.V.E., J.K.W., M.W., S.M.W., S.-Y.W., S.W.-S., T.W.W., X.W., Z.W., L.K.W., J.S.W., M.K.W., J.J.Y., L.R.Y., T.R.Y., A.B.Z., J.Z., J.M.Z., J.H.Z., K.A.Z., N.A.Z., R.G.Z., W. Zhao, W Zheng, X.Z. and Y.Z.
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A list of contributing members appears in the Supplementary Note.
A list of contributing members appears in the Supplementary Note.
A list of contributing members appears in the Supplementary Note.
A list of contributing members appears in the Supplementary Note.
Supplementary information
Supplementary Text and Figures
Supplementary Tables 1–18, Supplementary Figures 1–9 and Supplementary Note (PDF 7576 kb)
Supplementary Table 19
Comprehensive results of the biofeature analysis for the three novel loci (XLS 190 kb)
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Monda, K., Chen, G., Taylor, K. et al. A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nat Genet 45, 690–696 (2013). https://doi.org/10.1038/ng.2608
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DOI: https://doi.org/10.1038/ng.2608
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