Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Public health implications from COGS and potential for risk stratification and screening

Nature Genetics volume 45, pages 349–351 (2013)Cite this article

Subjects

Abstract

The PHG Foundation led a multidisciplinary program, which used results from COGS research identifying genetic variants associated with breast, ovarian and prostate cancers to model risk-stratified prevention for breast and prostate cancers. Implementing such strategies would require attention to the use and storage of genetic information, the development of risk assessment tools, new protocols for consent and programs of professional education and public engagement.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

Buy

All prices are NET prices.

References

  1. Anonymous. Nat. Genet. published online; doi:10.1038/ng.2592 (27 March 2013).

    Article  CAS  PubMed  Google Scholar 

  2. Michailidou K . et al. Nat. Genet. published online; doi:10.1038/ng.2563 (27 March 2013).

    Article  CAS  PubMed  Google Scholar 

  3. Pharoah, P.D.P. et al. Nat. Genet. published online; doi:10.1038/ng.2564 (27 March 2013).

    Article  CAS  PubMed  Google Scholar 

  4. Eeles, R.A. et al. Nat. Genet. published online; doi:10.1038/ng.2560 (27 March 2013).

    Article  CAS  PubMed  Google Scholar 

  5. Rose, G. Int. J. Epidemiol. 14, 32–38 (1985).

    Article  CAS  PubMed  Google Scholar 

  6. Burton, H., Sagoo, G.S., Pharoah, P. & Zimmern, R.L. Ital. J. Public Health 9, 4 (2012).

    Google Scholar 

  7. Garcia-Closas, M. et al. Nat. Genet. published online; doi:10.1038/ng.2561 (27 March 2013).

    Article  CAS  PubMed  Google Scholar 

  8. Bojesen, S.E. et al. Nat. Genet. published online; doi:10.1038/ng.2566 (27 March 2013).

    Article  CAS  PubMed  Google Scholar 

  9. French, J.D. et al. Am. J. Hum. Genet. published online; doi:10.1016/j.ajhg.2013.01.002 (27 March 2013).

  10. Shen, H. Nat. Comm. published online; 10.1038/ncomms2629 (27 March 2013).

  11. Permuth-Wey, J. et al. Nat. Comm. published online; doi:10.1038/ncomms2613 (27 March 2013).

  12. Kote-Jarai, Z. et al. Hum. Mol. Genet. published online; doi:10.1093/hmg/ddt086 (27 March 2013).

  13. Pashayan, N. et al. Br. J. Cancer 104, 1656–1663 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Fredholm, H. et al. PLoS ONE 4, e7695 (2009).

    Article  PubMed  PubMed Central  Google Scholar 

  15. Lin, D.W., Porter, M. & Montgomery, B. Cancer 115, 2863–2871 (2009).

    Article  PubMed  Google Scholar 

  16. Chowdhury, S. et al. Genet. Med. published online; doi:10.1038/gim.2012.167 (14 February 2013).

    Article  PubMed  PubMed Central  Google Scholar 

  17. Dent, T. et al. Public Health Genomics published online; doi:10.1159/000345941 (26 January 2013).

  18. UK Parliament. Human Tissue Act 2004 Chapter 30 (The Stationery Office, London, 2004).

  19. Antoniou, A. et al. Am. J. Hum. Genet. 72, 1117–1130 (2003).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Zheng, W. et al. Nat. Genet. 45, 191–196 (2013).

    Article  PubMed  Google Scholar 

  21. Independent UK Panel on Breast Cancer Screening. Lancet 380, 1778–1786 (2012).

Download references

Acknowledgements

H.B., S.C., T.D. and A.H. were supported by the PHG Foundation. The PHG Foundation is the working name of the Foundation for Genomics and Population Health, a charitable company registered in England and Wales: Charity 118664, Company 5823194. N.P. is supported by a Cancer Research UK Clinician Scientist Fellowship. This work is part of the COGS program, funded by the seventh Framework Programme of the European Commission under grant agreement 223175 (HEALTH-F2-2009-223175).

Author information

Authors and Affiliations

  1. PHG Foundation (Foundation for Genomics and Population Health), Cambridge, UK

    Hilary Burton, Susmita Chowdhury, Tom Dent & Alison Hall

  2. University College London (UCL) Department of Applied Health Research, University College London, London, UK

    Nora Pashayan

  3. Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK

    Paul Pharoah

  4. Department of Oncology, University of Cambridge, Cambridge, UK

    Paul Pharoah

Authors
  1. Hilary Burton
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Susmita Chowdhury
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tom Dent
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Alison Hall
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Nora Pashayan
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Paul Pharoah
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hilary Burton.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Burton, H., Chowdhury, S., Dent, T. et al. Public health implications from COGS and potential for risk stratification and screening. Nat Genet 45, 349–351 (2013). https://doi.org/10.1038/ng.2582

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng.2582

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer