The PHG Foundation led a multidisciplinary program, which used results from COGS research identifying genetic variants associated with breast, ovarian and prostate cancers to model risk-stratified prevention for breast and prostate cancers. Implementing such strategies would require attention to the use and storage of genetic information, the development of risk assessment tools, new protocols for consent and programs of professional education and public engagement.
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H.B., S.C., T.D. and A.H. were supported by the PHG Foundation. The PHG Foundation is the working name of the Foundation for Genomics and Population Health, a charitable company registered in England and Wales: Charity 118664, Company 5823194. N.P. is supported by a Cancer Research UK Clinician Scientist Fellowship. This work is part of the COGS program, funded by the seventh Framework Programme of the European Commission under grant agreement 223175 (HEALTH-F2-2009-223175).
The authors declare no competing financial interests.
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Burton, H., Chowdhury, S., Dent, T. et al. Public health implications from COGS and potential for risk stratification and screening. Nat Genet 45, 349–351 (2013). https://doi.org/10.1038/ng.2582
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