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RNF212 marks the spot

Nature Genetics volume 45, pages 228229 (2013) | Download Citation

A new study in mice shows that, during meiosis, the decision to mature a double-strand break into a crossover is controlled by a dosage-sensitive regulator, RNF212. This finding provides insight into the crossover maturation process and may help explain how sequence polymorphisms in RNF212 alter the frequency of crossing over in humans.

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References

  1. 1.

    & Science 301, 785–789 (2003).

  2. 2.

    Curr. Top. Dev. Biol. 52, 1–53 (2001).

  3. 3.

    et al. Nat. Genet. 45, 269–278 (2013).

  4. 4.

    et al. Science 319, 1398–1401 (2008).

  5. 5.

    & Cell 102, 245–255 (2000).

  6. 6.

    et al. Mol. Cell Biol. 24, 7998–8006 (2004).

  7. 7.

    , , & PLoS Genet. 4, e1000235 (2008).

  8. 8.

    , , & J. Biomed. Sci. 14, 481–490 (2007).

  9. 9.

    et al. PLoS Genet. 8, e1002809 (2012).

  10. 10.

    et al. PLoS Genet. 8, e1002799 (2012).

  11. 11.

    et al. PLoS Genet. 3, e139 (2007).

Download references

Author information

Affiliations

  1. Cathleen M. Lake and R. Scott Hawley are at the Stowers Institute for Medical Research, Kansas City, Missouri, USA.

    • Cathleen M Lake
    •  & R Scott Hawley
  2. R. Scott Hawley is also affiliated with the Department of Molecular and Integrative Physiology, Kansas University Medical Center, Kansas City, Kansas, USA.

    • R Scott Hawley

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  1. Search for Cathleen M Lake in:

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to R Scott Hawley.

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DOI

https://doi.org/10.1038/ng.2559

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