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RNF212 marks the spot

A new study in mice shows that, during meiosis, the decision to mature a double-strand break into a crossover is controlled by a dosage-sensitive regulator, RNF212. This finding provides insight into the crossover maturation process and may help explain how sequence polymorphisms in RNF212 alter the frequency of crossing over in humans.

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Figure 1: Model of how recombination sites are marked to become crossovers.

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Correspondence to R Scott Hawley.

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Lake, C., Hawley, R. RNF212 marks the spot. Nat Genet 45, 228–229 (2013). https://doi.org/10.1038/ng.2559

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