Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

RNF212 marks the spot

Nature Genetics volume 45, pages 228–229 (2013)Cite this article

Subjects

A new study in mice shows that, during meiosis, the decision to mature a double-strand break into a crossover is controlled by a dosage-sensitive regulator, RNF212. This finding provides insight into the crossover maturation process and may help explain how sequence polymorphisms in RNF212 alter the frequency of crossing over in humans.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Model of how recombination sites are marked to become crossovers.

References

  1. Page, S.L. & Hawley, R.S. Science 301, 785–789 (2003).

    Article  CAS  Google Scholar 

  2. Keeney, S. Curr. Top. Dev. Biol. 52, 1–53 (2001).

    Article  CAS  Google Scholar 

  3. Reynolds, A. et al. Nat. Genet. 45, 269–278 (2013).

    Article  CAS  Google Scholar 

  4. Kong, A. et al. Science 319, 1398–1401 (2008).

    Article  CAS  Google Scholar 

  5. Agarwal, S. & Roeder, G.S. Cell 102, 245–255 (2000).

    Article  CAS  Google Scholar 

  6. Jantsch, V. et al. Mol. Cell Biol. 24, 7998–8006 (2004).

    Article  CAS  Google Scholar 

  7. Bhalla, N., Wynne, D.J., Jantsch, V. & Dernburg, A.F. PLoS Genet. 4, e1000235 (2008).

    Article  Google Scholar 

  8. Cheng, C.H., Lin, F.M., Lo, Y.H. & Wang, T.F. J. Biomed. Sci. 14, 481–490 (2007).

    Article  CAS  Google Scholar 

  9. Wang, K. et al. PLoS Genet. 8, e1002809 (2012).

    Article  CAS  Google Scholar 

  10. Chelysheva, L. et al. PLoS Genet. 8, e1002799 (2012).

    Article  CAS  Google Scholar 

  11. Ward, J.O. et al. PLoS Genet. 3, e139 (2007).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Cathleen M. Lake and R. Scott Hawley are at the Stowers Institute for Medical Research, Kansas City, Missouri, USA.,

    Cathleen M Lake & R Scott Hawley

  2. R. Scott Hawley is also affiliated with the Department of Molecular and Integrative Physiology, Kansas University Medical Center, Kansas City, Kansas, USA.,

    R Scott Hawley

Authors
  1. Cathleen M Lake
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R Scott Hawley
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to R Scott Hawley.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lake, C., Hawley, R. RNF212 marks the spot. Nat Genet 45, 228–229 (2013). https://doi.org/10.1038/ng.2559

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng.2559

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing