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The evolutionary biography of chronic lymphocytic leukemia

A recent study shows that the life history of chronic lymphocytic leukemia is characterized by a complex and dynamic architecture involving the development of subclones with changing dominance over time. This innovative study provides a framework to design anticipation-based chemotherapy approaches for cancer treatment.

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Figure 1: Effect of tumor heterogeneity on CLL evolution and treatment.


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Correspondence to Carlos López-Otín.

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Puente, X., López-Otín, C. The evolutionary biography of chronic lymphocytic leukemia. Nat Genet 45, 229–231 (2013).

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