We carried out a genome-wide association study of lung cancer (3,259 cases and 4,159 controls), followed by replication in 2,899 cases and 5,573 controls. Two uncorrelated disease markers at 5p15.33, rs402710 and rs2736100 were detected by the genome-wide data (P = 2 × 10−7 and P = 4 × 10−6) and replicated by the independent study series (P = 7 × 10−5 and P = 0.016). The susceptibility region contains two genes, TERT and CLPTM1L, suggesting that one or both may have a role in lung cancer etiology.
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Hung, R.J. et al. Nature 452, 633–637 (2008).
Amos, C.I. et al. Nat. Genet. 40, 616–622 (2008).
Thorgeirsson, T. et al. Nature 452, 638–642 (2008).
Weinrich, S.L. et al. Nat. Genet. 17, 498–502 (1997).
Greider, C.W. et al. Cell 43, 405–413 (1985).
Lantuéjoul, S. et al. Int. J. Cancer 120, 1835–1841 (2007).
Hanahan, D. & Weinberg, R.A. Cell 100, 57–70 (2000).
Greider, C.W. et al. Nature 337, 331–337 (1989).
Janknecht, R. FEBS Lett. 564, 9–13 (2004).
Mavrogiannou, E. et al. Clin. Chem. 53, 53–61 (2007).
Wu, T.C. et al. Lung Cancer 41, 163–169 (2003).
Savage, S.A. et al. Hum. Mutat. 26, 343–350 (2005).
Armanios, M. et al. Proc. Natl. Acad. Sci. USA 102, 15960–15964 (2005).
Garcia, C.K. et al. Nucleic Acids Res. 35, 7406–7416 (2007).
Yamamoto, K. et al. Biochem. Biophys. Res. Commun. 280, 1148–1154 (2001).
The authors thank all of the participants who took part in this research and the funders and support and technical staff who made this study possible. Support for the central Europe, HUNT2/Tromsø and CARET genome-wide studies and follow-up genotyping was provided by Institut National du Cancer, France. Support for the HUNT2/Tromsø genome-wide study was also provided by the European Community (Integrated Project DNA repair, grant no. LSHG-CT-2005-512113), the Norwegian Cancer Association and the Functional Genomics Programme of Research Council of Norway. Funding for the Toronto genome-wide study was provided by the Ontario Institute of Cancer Research. Funding for the Szczecin/Poland replication study was provided by European Community program “Marie-Curie Host Fellowships for the Transfer of Knowledge,” grant no. MTKD-CT-2004-510114. Additional funding for study coordination, genotyping of replication studies and statistical analysis was provided by the US National Cancer Institute (R01 CA092039).
A full list of authors appears at the end of this paper.
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McKay, J., Hung, R., Gaborieau, V. et al. Lung cancer susceptibility locus at 5p15.33. Nat Genet 40, 1404–1406 (2008). https://doi.org/10.1038/ng.254
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