News & Views | Published:

Loss of function of the new interferon IFN-λ4 may confer protection from hepatitis C

Nature Genetics volume 45, pages 119120 (2013) | Download Citation

Attempts to elucidate the mechanism underpinning the genetic association between IFNL3, previously called IL28B, and clearance of hepatitis C virus have, by and large, been unsuccessful. A study in this issue suggests that a new gene, IFNL4, may be responsible.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    et al. Nature 461, 399–401 (2009).

  2. 2.

    et al. Nat. Genet. 41, 1100–1104 (2009).

  3. 3.

    et al. Nat. Genet. 41, 1105–1109 (2009).

  4. 4.

    et al. Gastroenterology 138, 1338–1345 (2010).

  5. 5.

    et al. Nat. Genet. 45, 164–171 (2013).

  6. 6.

    et al. Hepatology 52, 1888–1896 (2010).

  7. 7.

    et al. Gastroenterology 140, 1021–1031 (2011).

  8. 8.

    et al. Gastroenterology 139, 499–509 (2010).

  9. 9.

    et al. Hepatology 56, 444–454 (2012).

  10. 10.

    et al. Genome Med. 3, 57 (2011).

  11. 11.

    et al. Hepatology 54, Suppl. 1 (2011).

  12. 12.

    et al. J. Hepatol. 54, Suppl. 1 (2011).

  13. 13.

    et al. J. Hepatol. 56, Suppl. 2 (2012).

  14. 14.

    et al. Gastroenterology 142, 790–795 (2012).

Download references

Author information

Affiliations

  1. David Booth is at the Institute for Immunology and Allergy Research, Westmead Millennium Institute, University of Sydney, Sydney, New South Wales, Australia.

    • David Booth
  2. Jacob George is at the Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney, Sydney, New South Wales, Australia.

    • Jacob George

Authors

  1. Search for David Booth in:

  2. Search for Jacob George in:

Competing interests

D.B. and J.G. have filed patent applications in Australia and the United States for use of the IL28B gene region to predict drug response.

Corresponding author

Correspondence to Jacob George.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/ng.2537

Further reading

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing