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A tumor-specific stem cell

Nature Genetics volume 45, pages 7–9 (2013)Cite this article

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Cancer stem cells are thought to share many characteristics with their normal stem cell counterparts, raising concerns about the ability to selectively target them. A new study shows that Dclk1 marks cancer, but not normal, stem cells in the intestine and that targeting this population results in adenoma collapse without affecting normal tissue.

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Figure 1: Intestinal CSCs are distinct from NSCs.

References

  1. Clevers, H. Nat. Med. 17, 313–319 (2011).

    Article  CAS  Google Scholar 

  2. Nakanishi, Y. et al. Nat. Genet. 45, 98–103 (2013).

    Article  CAS  Google Scholar 

  3. May, R. et al. Stem Cells 26, 630–637 (2008).

    Article  Google Scholar 

  4. Gerbe, F., Brulin, B., Makrini, L., Legraverend, C. & Jay, P. Gastroenterology 137, 2179–2180 (2009).

    Article  CAS  Google Scholar 

  5. Barker, N. et al. Nature 449, 1003–1007 (2007).

    Article  CAS  Google Scholar 

  6. Schepers, A. G. et al. Science 337, 730–735 (2012).

    Article  CAS  Google Scholar 

  7. Polakis, P. Curr. Opin. Pharmacol. 5, 382–387 (2005).

    Article  CAS  Google Scholar 

  8. Tian, H. et al. Nature 478, 255–259 (2011).

    Article  CAS  Google Scholar 

  9. Chen, J. et al. Nature 488, 522–526 (2012).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Ciara Metcalfe and Frederic J. de Sauvage are in the Department of Molecular Biology at Genentech, Inc., South San Francisco, California, USA.,

    Ciara Metcalfe & Frederic J de Sauvage

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  1. Ciara Metcalfe
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  2. Frederic J de Sauvage
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Correspondence to Frederic J de Sauvage.

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Competing interests

The authors are employees of Genentech, Inc., and F.J.d.S. owns shares of Roche.

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Metcalfe, C., de Sauvage, F. A tumor-specific stem cell. Nat Genet 45, 7–9 (2013). https://doi.org/10.1038/ng.2502

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