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Clostridium difficile healthcare-associated epidemics

A new study reports whole-genome sequencing of a large collection of healthcare-associated C. difficile isolates, followed by comparative genomics and phylogenetic analyses. This work provides insight into the emergence of the current C. difficile epidemic 027/BI/NAP1 clone, which can be separated into two lineages on the basis of both SNPs and larger genetic changes mediated by mobile elements.

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Figure 1: Global expansion of C. difficile 027/BI/NAP1 lineages.

References

  1. Bartlett, J.G. Ann. NY Acad. Sci. 1213, 62–69 (2010).

    Article  Google Scholar 

  2. Kelly, C.P. & LaMont, J.T. N. Engl. J. Med. 359, 1932–1940 (2008).

    Article  CAS  Google Scholar 

  3. Kuijper, E.J., Coignard, B. & Tull, P. Clin. Microbiol. Infect. 12 (suppl. 6), 2–18 (2006).

    Article  CAS  Google Scholar 

  4. Riggs, M.M. et al. Clin. Infect. Dis. 45, 992–998 (2007).

    Article  Google Scholar 

  5. Clements, A.C., Magalhaes, R.J., Tatem, A.J., Paterson, D.L. & Riley, T.V. Lancet Infect. Dis. 10, 395–404 (2010).

    Article  Google Scholar 

  6. Muto, C.A. et al. Infect. Control Hosp. Epidemiol. 26, 273–280 (2005).

    Article  Google Scholar 

  7. Pépin, J., Valiquette, L. & Cossette, B. CMAJ 173, 1037–1042 (2005).

    Article  Google Scholar 

  8. He, M. et al. Nat. Genet. 45, 109–113 (2013).

    Article  CAS  Google Scholar 

  9. O'Connor, J.R., Johnson, S. & Gerding, D.N. Gastroenterology 136, 1913–1924 (2009).

    Article  CAS  Google Scholar 

  10. Brazier, J.S. et al. Euro Surveill. 13, pii: 19000 (2008).

    Article  Google Scholar 

  11. Bauer, M.P. et al. Lancet 377, 63–73 (2011).

    Article  Google Scholar 

  12. Kuijper, E.J. et al. Euro Surveill. 13, pii: 18942 (2008).

    Google Scholar 

  13. Stabler, R.A. et al. Genome Biol. 10, R102 (2009).

    Article  Google Scholar 

  14. Croucher, N.J. et al. Science 331, 430–434 (2011).

    Article  CAS  Google Scholar 

  15. Harris, S.R. et al. Science 327, 469–474 (2010).

    Article  CAS  Google Scholar 

Download references

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Correspondence to David A Rasko.

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Rasko, D. Clostridium difficile healthcare-associated epidemics. Nat Genet 45, 6–7 (2013). https://doi.org/10.1038/ng.2499

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