Cellular transformation in cancer has long been associated with aberrant DNA methylation, most notably, hypermethylation of promoter sequences. A new study uses a clever approach of selective high-resolution profiling to follow DNA methylation over a time course of cellular transformation and challenges the notion that hypermethylation in cancer arises in an orchestrated fashion.
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The authors declare no competing financial interests.
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Krebs, A., Schübeler, D. Tracking the evolution of cancer methylomes. Nat Genet 44, 1173–1174 (2012). https://doi.org/10.1038/ng.2451