Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

FOXA1 and breast cancer risk

Many SNPs associated with human disease are located in non-coding regions of the genome. A new study shows that SNPs associated with breast cancer risk are located in enhancer regions and alter binding affinity for the pioneer factor FOXA1.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: FOXA1 binding to its consensus DNA motif is affected by risk-associated SNPs that alter the binding affinity of DNA for FOXA1.

References

  1. Cowper-Salċlari, R. et al. Nat. Genet. 44, 1191–1198 (2012).

    Article  Google Scholar 

  2. Carroll, J.S. et al. Cell 122, 33–43 (2005).

    Article  CAS  Google Scholar 

  3. Pan, Y.F. et al. J. Biol. Chem. 283, 32977–32988 (2008).

    Article  CAS  Google Scholar 

  4. Fullwood, M.J. et al. Nature 462, 58–64 (2009).

    Article  CAS  Google Scholar 

  5. Zaret, K.S. & Carroll, J.S. Genes Dev. 25, 2227–2241 (2011).

    Article  CAS  Google Scholar 

  6. Easton, D.F. et al. Nature 447, 1087–1093 (2007).

    Article  CAS  Google Scholar 

  7. Meyer, K.B. et al. PLoS Biol. 6, e108 (2008).

    Article  Google Scholar 

  8. Jia, L. et al. PLoS Genet. 5, e1000597 (2009).

    Article  Google Scholar 

  9. Hurtado, A., Holmes, K.A., Ross-Innes, C.S., Schmidt, D. & Carroll, J.S. Nat. Genet. 43, 27–33 (2011).

    Article  CAS  Google Scholar 

  10. Udler, M.S. et al. Hum. Mol. Genet. 19, 2507–2515 (2010).

    Article  CAS  Google Scholar 

  11. Lupien, M. et al. Cell 132, 958–970 (2008).

    Article  CAS  Google Scholar 

  12. Kong, S.L., Li, G., Loh, S.L., Sung, W.K. & Liu, E.T. Mol. Syst. Biol. 7, 526 (2011).

    Article  Google Scholar 

  13. Easton, D.F. & Eeles, R.A. Hum. Mol. Genet. 17, R109–R115 (2008).

    Article  CAS  Google Scholar 

  14. Antoniou, A.C. et al. Am. J. Hum. Genet. 82, 937–948 (2008).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jason S Carroll.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Meyer, K., Carroll, J. FOXA1 and breast cancer risk. Nat Genet 44, 1176–1177 (2012). https://doi.org/10.1038/ng.2449

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng.2449

This article is cited by

Search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer